GENESITE Environmental Protection Technology Co., Ltd.
Calcium Ion Sensor Sensor
| Model ： | Ion Sensor |
| Place of Origin ： | China |
| DeliveryTime ： | 7-10 working days |
| MOQ ： | 1 PCS |
| Pay ： | TT,LC |
| Customized support ： | 144*144 |
| Warranty ： | 1 year |
| Accuracy ： | ±0.05%FS |
| Install Type ： | Immersion type /Flow through type |
| Principle ： | 0-50℃ |
| Protection grade ： | Ip68 |
| Output signal ： | RS-485,4-20mA |
| Product Name ： | 5m or customize |
| Temperature compensation ： | 0.1-18000ppm |
| Power Supply ： | DC 12V or DC 24V |
| Output signal ： | Stainless Steel |
Our Calcium Ion Sensor represents the forefront of live-cell imaging technology, providing researchers with an exceptionally reliable and sensitive tool for the real-time detection and quantification of intracellular calcium (Ca²⁺) dynamics. Engineered for superior performance, this genetically encoded calcium indicator (GECI) enables the precise visualization of transient calcium fluxes, which are critical secondary messengers in a vast array of cellular signaling pathways, including neuronal activity, muscle contraction, apoptosis, and hormone secretion.
This advanced biosensor is designed with a high-affinity calcium-binding motif, such as calmodulin (CaM) or troponin C, fused to a pair of fluorescent proteins that function via Förster Resonance Energy Transfer (FRET). Upon binding of calcium ions, a conformational change occurs, altering the energy transfer efficiency between the donor and acceptor fluorophores. This results in a measurable ratiometric change in fluorescence emission, allowing for quantitative analysis that is inherently resistant to variations in sensor concentration, photobleaching, and specimen thickness. This ratiometric property is crucial for obtaining accurate, reproducible data in complex experimental environments.
Key features of our Calcium Ion Sensor include its high dynamic range, ensuring a strong and clear signal-to-noise ratio upon calcium binding, and its optimized brightness for superior imaging clarity even in low-expression systems. The sensor exhibits appropriate binding kinetics, tailored to capture both rapid, spiking calcium transients and slower, oscillatory signals without buffering or perturbing the native calcium concentrations. It is available in multiple color variants (e.g., green-red FRET pairs or single-wavelength GFP-based proteins) to facilitate multiplexing with other optical tools and compatibility with standard microscope filter sets.
Ideal for a wide spectrum of applications, from fundamental neurobiological research and cardiac electrophysiology studies to high-throughput drug screening and diagnostics, our sensor provides unparalleled insight into cellular communication and function. Its genetically encoded nature allows for targeted expression in specific cell types, tissues, or subcellular compartments (e.g., cytosol, mitochondria, ER) using viral transduction or transgenic techniques, ensuring that the calcium signals you measure are from the precise population of interest.
Key Advantages:
Genetically Encoded: Enables targeted, long-term expression in specific cell types and subcellular locations.
Ratiometric Measurement: Provides quantitative data that is corrected for artifacts, ensuring high fidelity and reliability.
High Sensitivity & Dynamic Range: Detects subtle to large fluctuations in calcium concentrations with exceptional clarity.
Excellent Brightness & Photostability: Facilitates extended time-lapse imaging and reduces experimental noise.
Versatile Compatibility: Suitable for confocal microscopy, epifluorescence microscopy, flow cytometry, and microplate readers.
Unlock a deeper understanding of calcium-mediated signaling with our premium Calcium Ion Sensor, the trusted choice for scientists demanding accuracy, flexibility, and robust performance in their cellular imaging workflows.
Keywords:
Calcium Ion Sensor
Calcium Ion Sensor
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